Top 8 DeSci Projects in 2025

Top 8 DeSci Projects in 2025

Decentralized science, also known as DeSci, has undergone significant development in 2025. Something that began as a small, specialized area with limited attention within the broader crypto world now influences how scientific research is proposed, funded, published, and owned.

Old academic systems that were disrupted by open blockchain based alternatives now give more people access to funding, publishing, and research data.

These DeSci projects are frameworks where scientists can connect directly with funders, where patients can choose to share their health data for medical solutions, and where scientific discoveries can be owned, managed, and earn money through transparent blockchain systems with no single institution in control.

If you are already finding these projects interesting and can not wait to know about them in detail, we have written this comprehensive guide to put you through everything worth knowing.

1. OriginTrail (TRAC)

OriginTrail was developed for supply chain data verification, and has developed into life sciences, academic research, and complex networks of information designed for use in large organizations or industries. Its network allows scientific data to be indexed and verified across multiple stakeholders and does not need central repositories or intermediaries.

Through building a complex network of information for organizations use, OriginTail has enabled researchers and institutions to publish information that cannot be changed, deleted, or altered without detection, improving transparency.

It is currently used in sectors like pharmaceuticals, biotechnology, and academic publishing to ensure research integrity, and TRAC is the token that allows easy indexing, staking, and data validation in the ecosystem.

2. Hippocrat (HPO)

Hippocrat is designed to return data ownership to patients. The project is working with major healthcare apps in most Asian and European countries to allow individuals to choose how and when to share their medical data with research institutions or pharmaceutical companies.

See Hippocrat as a decentralized network where patients are also stakeholders, and can choose when and how their data is used, with researchers encouraged to reward them for it, making the project ideal in personalized medicine and public health studies.

3. VitaDAO (VITA)

VitaDAO allows contributors to combine their money into a shared fund, and then decide which scientific projects to be supported by voting instead of relying on government grants or institutional investors.

In 2025, VitaDAO has funded dozens of projects, collaborating with universities, biotech firms, and independent researchers. The DAO also tokenizes research results using IP-NFTs, creating a new way for licensing and sharing of revenue.

4. ResearchHub (RSC)

ResearchHub solves the issue of inefficiency in academic publishing as most academic journals are costly to access and very slow to publish new research. ResearchHub is an open alternative where researchers can publish findings, receive community feedback, and earn tokens as rewards.

The platform has developed into a community of scientists and science enthusiasts who collaboratively validate research in real time. RSC is the token of the project, it is used to reward users who improve research quality, support valuable insights, and keep misinformation in check.

5. Dynex (DNX)

Dynex, instead of centralized data centers, operates a distributed GPU network that researchers can use for high performance tasks such as molecular modeling, artificial intelligence training, and genomics analysis.

Dynex stands out from other DeSci projects because, instead of using energy on meaningless calculations, it uses its computing power to solve scientific problems, plus nodes are rewarded for contributing to actual research workloads, not just solving cryptographic puzzles.

6. AxonDAO (AXGT)

AxonDAO is working to change how ownership and control of scientific discoveries are managed. Instead of letting universities, corporations, or private institutions make all the decisions about patents, licenses, or research rights, AxonDAO uses a decentralized system where the community helps govern these assets.

Researchers submit proposals that are examined and funded by the DAO, which then holds a share of the resulting IP. AxonDAO also provides a marketplace for licensing research results and managing royalties.

7. HairDAO (HAIR)

HairDAO may appear to target a small issue, hair loss, but it showcases the power of DeSci. It proves that decentralized science can bring together people who care about a specific health problem, raise funds, and directly support the research that matters to them.

In 2025, it has funded multiple studies by getting capital from individuals directly affected by hair loss. In HairDAO, the community decides which research projects to support through a voting system. When those projects produce results, the findings are not hidden or locked away, they are openly shared with everyone involved.

8. Galeon (GALEON)

Galeon is creating a decentralized system for hospitals to securely share medical data with researchers. Through its infrastructure, hospitals can hide datasets and make them available for studies while complying with data protection laws.

Currently, the project is collaborating with healthcare institutions across Europe to enable ethical, tokenized access to health records. This setup is especially useful in areas like cancer research to monitor and respond to disease outbreaks, and study rare conditions that require large datasets from multiple hospitals to make progress.

Conclusion

DeSci is not a speculative trend in some sense as each of these projects represents a working alternative to the bureaucratic, centralized structures that have been applied in science for decades. They support faster funding, wider participation, open data, and shared ownership in research.

DeSci isn’t just trying to copy or replace traditional systems like universities, journals, or big pharma. Instead, it’s creating completely new ways for people to work together on science that are more open, transparent, and inclusive.

Now, it is not just scientists making decisions. Patients, investors, and regular people can directly participate in funding and guiding research. As a result, the old barriers of who creates science, who pays for it, and who benefits from are no longer effective.

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